PREPARATION OF FUSED POLYCYCLIC ALKALOIDS BY RING CLOSURE OF AZOMETHINE YLIDES, NOVEL COMPOUNDS THEREOF AND THEIR USE AS CHEMOTHERAPEUTIC AGENTS

摘要

A method for the preparation of a compound of general Formula (I) comprising the step of cyclizing an azomethine ylide of general Formula (II) wherein A is a cyclic group being an optionally substituted aryl group or an aromatic heterocyclic group; or A is a cyclic group R?A1RA2C-CRA3RA4¿ wherein R?A2 and RA3¿, together with the carbon atoms to which they are attached form an optionally substituted saturated or unsaturated carbocyclic or heterocyclic group and R?A1 and RA4¿ are as defined below or together form a bond; or A is a non-cyclic group R?A1RA2C-CRA3RA4¿ wherein R?A1 - RA4¿ are as defined below and R?A2 and RA3¿ may optionally together form a bond; Z is a carbon or a heteroatom; n is selected from 0, 1, 2 or 3; and R?A1 - R14¿, W, X and Y may be the same or different and each are selected from hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally protected hydroxy, optionally substituted amino, optionally substituted alkoxy, optionally substituted alkenoxy, optionally substituted alkynoxy, optionally substituted aryl, optionally substituted heterocyclyl, carboxy, carboxy ester, carboxamido, acyl, acyloxy, mercapto, optionally substituted alkylthio, halogen, nitro, sulfate, phosphate and cyano, or W and X, together with the nitrogen and carbon atoms to which they are attached, form a saturated or unsaturated nitrogen containing heterocyclic group which may be optionally substituted or optionally fused to a saturated or unsaturated carbocyclic group, aryl group or heterocyclic group; or pharmaceutically acceptable derivatives and salts, racemates, isomers and/or tautomers thereof.