Treatment of cancer by the administration of fas ligand expressing non-tumorigenic cells

摘要

The present invention provides a method of treating solid tumors wherein the cells of the tumor express the Fas receptor. The method comprises administering to the tumor cells non-tumorigenic cells which express the Fas ligand. The non-tumorigenic cells can be myoblasts which may be a naturally Fas deficient strain of primary skeletal myoblasts transduced with the gene encoding the Fas ligand. These non-tumorigenic cells can be administered to the tumor cells of interest either in vivo at a tumor site or a site from which a tumor has been removed or in vitro. The tumor cells can be rhabdomyosarcoma-derived tumor cells.