PEPTIDE DERIVATIVES, PROCESS OF THEIR PREPARATION AND USE

摘要

PCT No. PCT/GB97/00438 Sec. 371 Date Aug. 20, 1998 Sec. 102(e) Date Aug. 20, 1998 PCT Filed Feb. 18, 1997 PCT Pub. No. WO97/31023 PCT Pub. Date Aug. 28, 1997The invention concerns pharmaceutically useful peptide derivatives of the formula (I): P-R1-R2-R3-R4, in which P, R1, R2, R3, and R4 have the various meanings defined herein, and their pharmaceutically acceptable salts, and pharmaceutical compositions containing them. The novel peptide derivatives are of value in treating MHC class II dependent T-cell mediated autoimmune or inflammatory diseases, such as rheumatoid arthritis. The invention further concerns processes for the manufacture of the novel peptide derivatives and the use of the compounds in medical treatment.