| 发明名称 |
VARIANTS OF THYMIDINE-KINASE, DNA SEQUENCES ENCODING THEREOF AND THEIR USE IN GENE THERAPY |
| 摘要 |
<p>The present invention relates to a nucleic acid sequence characterized in that it is derived from the wild nucleic acid sequence coding for a thymidine kinase, said nucleic acid sequence having at least one mutation in the region corresponding to the ATP binding site and conveniently a second mutation in the N-terminal region and/or C-terminal region. It also relates to variants of the wild thymidine kinase and their use in genic therapy.</p> |
| 申请公布号 |
CZ9802479(A3) |
申请公布日期 |
1998.11.11 |
| 申请号 |
CZ19980002479 |
申请日期 |
1997.01.31 |
| 申请人 |
RHONE-POULENC RORER S.A. |
发明人 |
CROUZET JOEL;BLANCHE FRANCIS;COUDER MICHEL;CAMERON BEATRICE |
| 分类号 |
C12N15/09;A61K31/00;A61K31/70;A61K31/7088;A61K31/711;A61K38/00;A61K48/00;A61P35/00;C12N9/12;C12N15/38;(IPC1-7):C12N15/54;A61K38/45 |
主分类号 |
C12N15/09 |
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