DONOR KIDNEY VIABILITY TEST FOR IMPROVED PRESERVATION

摘要

The present invention contemplates a methodology which employs cold perfusion of donor organs with a colloid preservation solution at a selected perfusion pressure which avoids tubular reabsorption and consequent energy loss. The present invention is also directed towards the direct continuous measurement of Glomerular Filtration Rate (GFR) through measurement of urine formation during the perfusion period. The present invention further provides a method to assess afferent arteriole and efferent arteriole vascular patency. The present invention further contemplates the maintenance of tubular patency during perfusion. The present invention is also directed to a method for monitoring cold ischemia damage as an indication for timing and dosage of nephrotoxic immunosuppressant agents, e.g., Cyclosporin A. The present invention still further contemplates a device for performing the test of the present invention.