| 摘要 |
The present invention relates to a synthetic peptide derived from TGF- beta and mimicking TGF- beta activity, which peptide comprises at least 4 consecutive amino acids from one of the sequences CFSSTEKNCCVR, FSSTEKNCCVRQ, EKNCCVRQLYID, NCCVRQLYIDFR, CCVRQLYIDFRK, LYIDFRKDLGWK, FRKDLGWKWIHE, RKDLGWKWIHEP, HEPKGYHANFCL, TQYSKVLALYNQ, YSKVLALYNQHN, LYNQHNPGASAA, EQLSNMIVSCK, or LSNMIVRSCKCS, which peptide is between 4 and 18 amino acids in length; a pharmaceutical composition comprising said peptides as well as a pharmaceutical composition comprising TGF- beta 1 and at least one synthetic peptide derived from TGF- beta and mimicking TGF- beta activity, which peptide comprises at least 4 consecutive amino acids from one of the sequences KNCCVRQLYIDF, NCCVRQLYIDFR, CCVRQLYIDFRK, CVRQLYIDFRKD, VRQLYIDFRKDL, RQLYIDFRKDLG, HEPKGYHANFCL, EPKGYHANFCLG, TQYSKVLALYNQ, YSKVLALYNQH, KVLALYNQHNP, NQHNPGASAAPC, QHNPGASAAPCC, HNPGASAAPCCV, PKVEQLSNMIVR or LSNMIVRSCKCS, which peptide is between 4 and 18 amino acids in length, together with at least one suitable excipient for administration. |
