Synthesis of the sulfonylpyrimidine derivatives with anticancer activity

摘要

This invention relates to the processes for the preparation of unknown N-1 sulfonyl and N-1,NH-4 disulfonyl derivatives of pyrimidine nucleo bases, general formulae I, II, III, IV, V and VI, and their biological activity. This type of compounds exhibits strong anticancer activity in vitro on different tumor cell lines whereas cytostatic behavior on normal human fibroblasts is much less pronounced.