发明名称 |
Bispecific molecules for use in inducing antibody dependent effector cell-mediated cytotoxicity |
摘要 |
Bispecific molecules comprising a non-immunoglobulin tumor cell specific ligand and an antibody which binds the Fc receptor of an effector cell at a site that is not inhibited by endogenous immunoglobulin are disclosed. The bispecific molecules can be used to induce a specific antibody dependent effector cell-mediated cytotoxicity against tumor cells, such as small cell lung carcinoma (SCLC) cells, either in vivo or in vitro.
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申请公布号 |
US5833985(A) |
申请公布日期 |
1998.11.10 |
申请号 |
US19950451194 |
申请日期 |
1995.05.26 |
申请人 |
MEDAREX, INC. |
发明人 |
BALL, EDWARD D.;FANGER, MICHAEL W. |
分类号 |
A61K38/00;A61K39/395;A61K47/48;C07K7/08;C07K14/595;C07K16/28;C07K16/46;C12P21/08;(IPC1-7):A61K39/385 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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