Methods of inhibiting the growth of neoplasia using a monoclonal antibody against alpha platelet derived growth factor receptor

摘要

Potent neutralizing monoclonal antibodies to the human alpha PDGF receptor ( alpha PDGFR) and fragments thereof are described. These monoclonal antibodies specifically bind to an epitope on alpha PDGFR, inhibits PDGF binding with PDGF, antagonizes PDGF, and does not bind beta PDGFR receptor. A hybridoma cell line producing such a monoclonal antibody, methods of in vivo imaging of a pathological conditions and methods of inhibiting the growth of a neoplasia expressing alpha PDGFR, which use these monoclonal antibodies are also described. In vitro assays for detecting the presence of alpha PDGFR and for evaluating the binding affinity of a test compound are also described.