| 摘要 |
PCT No. PCT/JP94/01411 Sec. 371 Date Feb. 23, 1996 Sec. 102(e) Date Feb. 23, 1996 PCT Filed Aug. 25, 1994 PCT Pub. No. WO95/06113 PCT Pub. Date Mar. 2, 1995Disclosed are a novel cytoplasmic tyrosine kinase which is increased with respect to expression amount thereof in accordance with the differentiation of blood cells, and a deoxyribonucleic acid (DNA) coding for the same. The tyrosine kinase of the present invention can be advantageously used for screening chemical substances having the capability to inhibit or activate the tyrosine kinase activity of at least the tyrosine kinase of the present invention. Also disclosed are a replicable recombinant DNA molecule comprising a replicable expression vector and, operably inserted in the vector, a DNA coding for the tyrosine kinase of the present invention; a microorganism or animal cells transformed with the replicable recombinant DNA molecule; an antibody reactive with a polypeptide comprising as an immunogen at least part of an amino acid sequence of the tyrosine kinase of the present invention; a sense DNA prepared from the cDNA coding for the tyrosine kinase of the present invention and an anti-sense DNA which is complementary to the sense DNA; and a sense RNA prepared from the cDNA coding for the tyrosine kinase of the present invention and an anti-sense RNA which is complementary to the sense RNA.
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