发明名称 |
Methods and compositions of growth control for cells encapsulated within bioartificial organs |
摘要 |
This invention relates to methods and compositions of controlling cell distribution within a bioartificial organ by exposing the cells to a treatment that inhibits cell proliferation, promotes cell differentiation, or affects cell attachment to a growth surface within the bioartificial organ. Such treatments include (1) genetically manipulating cells, (2) exposing the cells to a proliferation-inhibiting compound or a differentiation-inducing compound or removing the cells from exposure to a proliferation-stimulating compound or a differentiation-inhibiting compound; exposing the cells to irradiation, and (3) modifying a growth surface of the BAO with ECM molecules, molecules affecting cell proliferation or adhesion, or an inert scaffold, or a combination thereof. These treatments may be used in combination.
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申请公布号 |
US5833979(A) |
申请公布日期 |
1998.11.10 |
申请号 |
US19950447771 |
申请日期 |
1995.05.23 |
申请人 |
CYTOTHERAPEUTICS, INC. |
发明人 |
SCHINSTINE, MALCOLM;SHOICHET, MOLLY S.;GENTILE, FRANK T.;HAMMANG, JOSEPH P.;HOLLAND, LAURA M.;CAIN, BRIAN M.;DOHERTY, EDWARD J.;WINN, SHELLEY R.;AEBISCHER, PATRICK |
分类号 |
A01K67/027;A61K48/00;A61L27/00;A61L27/18;A61L27/22;A61L27/38;C07K14/82;C12N5/00;C12N5/10;C12N15/09;C12N15/12;(IPC1-7):A01N63/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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