| 摘要 |
3-Quinuclidinyl butanoate and propanoate antimuscarinic bronchodilators. purticu larly useful in the treatment of chronic obstructive airways disease and asthma, of formula (I), and their pharmaceutical ly acceptable salts, wherein X is either (a) a phenyl group optionally substituted by one or two substituents each independentl y selected from halo, CF3. C1-C4 alkyl,/C1-4 alkoxy and hydroxy or (b) a thienyl group: and "Het" is either (a) a 5-membered nitrogen-containing heterocylic group attached to the adjacent carbon atom either by a carbon or a ring nitrogen atom and which is selected from imidazolyl, pyrazolyl, triazolyl and tetrazolyl, (b) an oxadiazolyl or thiadiazolyl group at tached to the adjacent carbon atom by a carbon atom. or (c) a 6-membered nitrogen-containing heterocyclic group attached to th e adjacent carbon atom by a carbon atom and selected from pyridinyl, pyrazinyl, pyrimidinyl and pyridazinyl. "Het" being optionally substituted by up to two substituents each independently selected from halo, CF3, C1-C4 alkyl, C1-C4 alko xy, hydroxy, amino and azido; and m is 1 or 2.
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