Nucleic acids vectors and host cells encoding and expressing heregulin 2- alpha

摘要

Novel 2 polypeptides with binding affinity for the p185HER2 receptor, designated heregulin 2- alpha and heregulin 2- beta , have been identified and purified from human tissue. The cDNA encoding the novel heregulin 2- alpha has been isolated from human tissue and sequenced. Provided herein is nucleic acid sequence of the heregulin 2- alpha useful in the production of heregulin 2- alpha by recombinant means. Further provided an amino acid sequence of heregulin 2- alpha and heregulin 2- beta . Heregulins and their antibodies are useful as therapeutic agents and in diagnostic methods.