| 摘要 |
PROBLEM TO BE SOLVED: To inexpensively obtain a large amount of vitamin K useful as a remedy for osteoporosis, having osteogenesis-promoting activity and osteroclasis- suppressive activity by adding a specified amount of glycerol to soybean broth, and after pH adjustment, inoculating the above mixture with Bacillus natto, followed by culturing according to a conventional method. SOLUTION: The objective vitamin K useful as a remedy for osteoporosis, etc., having osteogenesis-promoting activity and asteoclasis suppressive activity and clearly capable of increasing the bone density through its administration, and useful for inexpensive production of cultured product having extremely high vitamin K content, is inexpensively obtained in large amount by diluting soybean broth as a by-product during natto production to make a concentration as Brix of 5-10%, adjusting it to pH 7, adding glycerol at >=1 wt.%, preferably, at 3-10 wt.%, putting the mixture into a jar fermenter, then, inoculating it with Bicillus natto, and culturing the inoculated system for 4 days at 40 deg.C under aerated stirring. |
