Process for the preparation of 3-amino-2-hydroxy-4-phenylbutyronitrile derivatives

摘要

3-Amino-2-hydroxy-4-phenylbutyronitrile derivatives represented by the formula (3) may be prepared by reacting an aminoaldehyde derivative represented by the formula (1) with a cyanohydrin derivative represented by the formula (2) in the presence of a metallic compound, base, or acid; <IMAGE> (1) <IMAGE> (2) <IMAGE> (3) wherein R1 and R2 each independently represents a hydrogen atom or a protective group for an amino group, R3 and R4 each represents an alkyl or cycloalkyl group or R3 and R4 together form a tetramethylene or pentamethylene group.