发明名称 |
LIGANDS FOR DISCOIDIN DOMAIN RECEPTOR TYROSINE KINASES AND COMPLEXES THEREOF |
摘要 |
Members of the collagen family are ligands for the discoidin domain receptor tyrosine kinases, DDR1 and DDR2. Collagen directly interacts with the extracellular domains and evokes tyrosine phosphorylation of DDRs in a time and concentration dependent manner. Collagen activation of DDR1 induced phosphorylation of a docking site for the Shc phosphotyrosine binding domain. Therefore, isolated complexes are described comprising (a) a discoidin domain receptor tyrosine kinase or a part thereof, and a collagen or a part thereof; or (b) a discoidin domain receptor tyrosine kinase or a part thereof and Shc or PTB binding domain of Shc or a protein containing a PDZ domain or a PDZ domain. Compositions, methods, and uses are also described based on the interaction of DDRs with collagens. |
申请公布号 |
WO9834954(A3) |
申请公布日期 |
1998.11.05 |
申请号 |
WO1998CA00093 |
申请日期 |
1998.02.05 |
申请人 |
MOUNT SINAI HOSPITAL CORPORATION;VOGEL, WOLFGANG;PAWSON, ANTHONY |
发明人 |
VOGEL, WOLFGANG;PAWSON, ANTHONY |
分类号 |
G01N33/53;A61K38/00;A61K38/17;A61K38/39;A61K38/45;A61K39/395;A61K45/00;A61P43/00;C07K14/705;C07K14/78;C12N9/12 |
主分类号 |
G01N33/53 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|