| 摘要 |
<p>The present invention relates to the field of biotechnology, particularly to the development of recombinant fusion proteines based on bacterial adhesines and their use in diagnostic assays of hemagglutination for the specific detection of antibodies or antigenes in the blood and other biological samples. The object from a technical point of view is to obtain recombinant fusion proteines, or biochemical conjugates, useful for the development of simple diagnostic assay sytems based on bacterial adhesines or their domains of molecular interaction with red cells. The use of adhesion proteines of E. coli as a base of fusion recombinant proteines with an activity of union to human erythrocytes enhances the characteristics of expression in said host thereby eliminating potential problems in production yields associated to bacterial toxicity.</p> |
