| 摘要 |
<p>Compounds of formula (I), wherein Rl is an aromatic or a heteroaromatic ring; R?2 and R3¿ are H, C¿1?-C8alkyl, aryl, arylC1-C8alkyl, or heteroaryl; R?4¿ is an aromatic or a heteroaromatic ring or an amine; W, X, Y, are independently selected from the group consisting of CH, N, S, or O, provided that at least one of W, X, and Y is a heteroatom, which inhibit protease, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease therewith.</p> |
