发明名称 |
SULFONAMIDE COMPOUNDS AND SALTS FOR TREATMENT OF ENDOTHELIN-MEDIATED DISORDERS |
摘要 |
Thienyl-, furyl- and pyrrolyl-sulfonamides, pharmaceutically-acceptable salts of sulfonamides, formulations of salts and the sulfonamides, and methods for modulating or altering the activity of the endothelin family of peptides using the formulations and sulfonamides are provided. In particular, formulations of sodium salts of N-(isoxazolyl)thienylsulfonamides, N (isoxazolyl)furylsulfonamides and N-(isoxazolyl)pyrrolylsulfonamides are provided. A process of preparing an alkali metal salt of a hydrophobic sulfonamide is provided. The process includes the step of dissolving a free sulfonamide in an organic solvent in the presence of a saturated alkali metal salt solution and recovering the formed sulfonamide salt from the organic phase.
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申请公布号 |
CA2281090(A1) |
申请公布日期 |
1998.11.05 |
申请号 |
CA19982281090 |
申请日期 |
1998.04.02 |
申请人 |
TEXAS BIOTECHNOLOGY CORPORATION |
发明人 |
BLOK, NATALIE;WU, CHENGDE;KOGAN, TIMOTHY P.;KELLER, KARIN;WOODARD, PATRICIA |
分类号 |
A61K9/08;A61K9/19;A61K9/20;A61K9/48;A61K31/422;A61K47/10;A61K47/12;A61K47/26;A61K47/36;A61K47/38;A61P1/00;A61P1/04;A61P5/24;A61P9/00;A61P9/08;A61P9/10;A61P9/12;A61P11/00;A61P11/06;A61P11/08;A61P13/12;A61P15/00;A61P17/02;A61P27/02;A61P27/06;A61P29/00;A61P37/00;A61P43/00;C07D261/00;C07D261/16;C07D333/00;C07D409/12;C07D413/12;C07D413/14;C07D417/14;(IPC1-7):C07D413/12;A61K31/42 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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