发明名称 |
NEURONAL MORT1 ISOFORMS |
摘要 |
A MORT1 gene initially cloned from HeLa cells and identified as a member of the receptor mediated apoptotic pathway, is expressed in the human neuronal cell line, NTERA2. Isolation of the MORT1 from this cell line revealed a transcript isoform that differed from the known MORT1 sequence by a deletion of 21 base pairs (bp 172-192 of the coding sequence). Cloning of MORT1 from adult human brain revealed two isoforms, one similarly deleted for bp 172-192, the other with a basepair substitution, A for G at position 173. Assessment of MORT1 function in a yeast two hybrid system indicates that the deleted and intact forms of MORT1 differ in their capacity to interact with other members of the apoptotic pathway.
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申请公布号 |
CA2287537(A1) |
申请公布日期 |
1998.11.05 |
申请号 |
CA19982287537 |
申请日期 |
1998.04.14 |
申请人 |
AMERICAN HOME PRODUCTS CORPORATION |
发明人 |
BINGHAM, BRENDAN WILLIAM;YOUNG, KATHLEEN H.;WOOD, ANDREW TIMOTHY;BIRSAN, CAMELIA |
分类号 |
C12N15/09;C07K14/47;C07K14/715;C12N15/12;(IPC1-7):C12N15/12 |
主分类号 |
C12N15/09 |
代理机构 |
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地址 |
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