| 摘要 |
<p>A mouse cDNA encoding a protein having a serine/threonine protein kinase region has been successfully isolated by effecting PCR with the use of a synthetic DNA corresponding to the kinase-conserved region as a primer and a cDNA originating in rates as a template and screening a mouse cDNA library by using the DNA fragment thus obtained as a probe. By using the sequence of the isolated mouse cDNA, cDNAs originating in human being and mice and being similar in structure to the above mouse cDNA have been successfully isolated too. Further, an antisense DNA against the isolated mouse cDNA is synthesized and its effects on nerve cells have been studied to find out that the above antisense DNA inhibits the extension of neurites in practice.</p> |
