OLIGOPEPTIDIC INHIBITORS OF ELASTASES AND METHODS OF PREPARATION THEREOF

摘要

The invention relates to oligopeptidic inhibitors of elastases, with potent inhibition of leukocyte elastase. The inhibitors are isobutylamides of tetra- to pentapeptides which have substituted lysine incorporated in the N-terminal portion of the molecule. This dibasic aminoacid is alternatively substituted at both alpha - and epsilon -aminogroups with higher saturated acids or with omega -carboxylalkanoylic residues. In one type of these compounds the epsilon -aminogroup is acylated with an acyl-alanine, where an acyl means a higher saturated acid. The compounds of this invention are the active components of medicinal preparations used mainly in dental practice.