| 发明名称 |
NGF VARIANTS |
| 摘要 |
NGF variants which have trkC-binding activity and trkC-signal inducing activity are provided. The variants optionally have trkA or trkB binding and signal induction activity. The NGF variants of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the NGF variant neurotrophins are also provided.
|
| 申请公布号 |
CA2286558(A1) |
申请公布日期 |
1998.11.05 |
| 申请号 |
CA19982286558 |
申请日期 |
1998.04.23 |
| 申请人 |
GENENTECH, INC. |
发明人 |
PRESTA, LEONARD G.;URFER, ROMAN;WINSLOW, JOHN W. |
| 分类号 |
C12N15/09;A61K38/00;A61K38/22;A61P25/00;C07K14/48;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/18;C12P21/02;C12R1/91;(IPC1-7):C12N15/18;A61K38/18;C12N15/85 |
主分类号 |
C12N15/09 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
