INHIBITORS OF NUCLEAR PROTEIN/NUCLEAR RECEPTOR INTERACTION

摘要

A method for identifying inhibitor compounds capable of reducing the interaction between a first region which is a signature motif on a nuclear protein, and a second region which is that part of a nuclear receptor which is capable of interacting with the nuclear protein through binding to the signature motif, wherein: the nuclear protein is a bridging factor that is responsible for the interaction between a liganded nuclear receptor and a transcription initiation complex involved in regulation of gene expression; the nuclear receptor is a transcription factor, the signature motif is a short sequence of amino acid residues which is the key structural element of a nuclear protein which binds to a liganded nuclear receptor as part of the process of the activation or repression of target genes.