发明名称 |
BIODEGRADABLE COMPOSITIONS COMPRISING POLY(CYCLOALIPHATIC PHOSPHOESTER) COMPOUNDS, ARTICLES, AND METHODS FOR USING THE SAME |
摘要 |
Biodegradable, flowable or flexible polymer compositions are described comprising a polymer having the recurring monomeric units shown in formula (I), wherein: each of R and R' is independently straight or branched alkylene, either unsubstituted or substituted with one or more non-interfering substituents; L is a divalent cycloaliphatic group; R'' is selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; and n is 5 to 1,000, wherein said biodegradable polymer is biocompatible before and upon biodegradation. In one embodiment, one or more of R, R' or R'' is a biologically active substance. Amorphous compositions containing a biologically active substance, in addition to the polymer, and methods for controllably releasing biologically active substances using the compositions, are also described.
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申请公布号 |
CA2288014(A1) |
申请公布日期 |
1998.11.05 |
申请号 |
CA19982288014 |
申请日期 |
1998.04.30 |
申请人 |
JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE;GUILFORD PHARMACEUTICALS INC. |
发明人 |
DANG, WENBIN;ENGLISH, JAMES P.;SHIPANOVA-KADIYALA, IRINA;ZHAO, ZHONG;LEONG, KAM W.;MAO, HAI-QUAN |
分类号 |
A61K47/30;A61K47/34;A61K47/48;A61L27/00;A61L27/18;A61L31/06;C08G79/04;C08K5/00;C08L85/02;(IPC1-7):A61L17/00;A61L25/00 |
主分类号 |
A61K47/30 |
代理机构 |
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