IMPROVED PROKARYOTIC EXPRESSION OF PROTEIN

摘要

The invention herein described relates to a novel prokaryotic expression system and proteins expressed thereby. The regulated expression or alteration of the wprA gene from the genome of B.subtilis has been shown to result in enhanced secretion of selected native, heterologous or recombinant polypeptides. This alteration provides the means by which the yield of secreted polypeptide is increased compared to strains carrying a wild type copy of the wprA gene.