| 摘要 |
<p>The present invention provides a vertebrate lens produced by selectively inducing lens development in vertebrate ectodermal cells. The vertebrate lenses of the present invention can be produced ectopically in a reliable manner, thereby providing an abundant source of vertebrate lenses for use in lens transplantation, as well as other medical procedures. Included are methods of using the lenses produced by the present invention. Also included are methods of treating a vertebrate with a defect in its lens development pathway, and related pharmaceutical compositions for such treatment. In addition, methods of identifying an agent that selectively induces the formation of a lens without inducing the formation of neural tissue are disclosed.</p> |
