摘要 |
<p>A method of preparing 2-[2-{[3-(1H-benzimidazol-2-yl)propyl]-methylamino}ethyl]-6-fluoro-1-isopropyl-1,2,3,4- tetrahydronaphthalen-2-yl methoxyacetate comprises contacting 6-fluoro-1- isopropyl-3,4-dihydro-1H-naphthalen-2-one with the anion of acetonitrile in an aprotic polar solvent; contacting [3-(1H-benzimidazol-2-yl) propyl]methylamine with the thus-formed (6-fluoro-2-hydroxy-1-isopropyl-1,2,3,4-tetrahydronaphthalen-2-yl)acetonitrile in the presence of hydrogen and a hydrogenation catalyst, followed by contacting the thus-formed 2-[2-{[3-(1H-benzimidazol-2-yl) propyl]methylamino}ethyl]-6-fluoro-1-isopropyl-1,2,3,4- tetrahydronaphthalen-2-ol with methoxyacetic acid or an activated derivative of methoxyacetic acid.</p> |