A method for making discodermolide and analogs thereof. The method utilizes three precursors which correspond to three subparts of discodermolide which are formed by disconnecting the discodermolide carbon backbone at positions C-7 to C-8 and C-15 to C-16. Coupling of the precursors is accomplished using chelation-controlled alkylation.
申请公布号
WO9848791(A1)
申请公布日期
1998.11.05
申请号
WO1998US08670
申请日期
1998.04.30
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;MYLES, DAVID, C.;HARRIED, SCOTT, S.;YANG, GE
