OLIGONUCLEOTIDE MEDIATED SPECIFIC CYTOKINE INDUCTION AND IN VIVO PROTECTION FROM INFECTION

摘要

The invention provides methods for modulating specific CMI-inducing cytokines in vivo. Such methods result in stimulation of the cytokines IL-6, IL-12 MIP-1β and MCP without substantially inducing undesired cytokines. The methods according to the invention are based upon administration of oligonucleotides containing particular structural motifs which lead to specific cytokine induction.