| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new compound useful as an asymmetric synthesis reagent for selectively producing optically active compounds. SOLUTION: A compound of formula I (R<1> is an alkyl; R<2> is H, an alkyl, an aryl, an aralkyl; * exhibits the position of an asymmetric carbon), e.g. (4R,5R)-4,5-diphenyl-1-methyl-3-phenylcarbamoyl-2-imidazolidinone. The compound of formula I can be obtained by subjecting an optically active 1,2-diphenyl-1,2- ethanediamine of formula II as a starting raw material to four processes, and subsequently reacting the obtained 4,5-diphenyl-1-alkyl-2-imidazodinone of formula III with an isocyanate compound of the formula: R<2> -N=C=O. The compound of formula I is reacted with a dialkylphoshite in diastereomer selectivity, and the obtained diastereomer is hydrolyzed to selectively give the optically activeα-aminophosphoric acid in a high yield. |
