发明名称 |
Purified sperm surface antigen, monoclonal antibody therefor and applications therefor |
摘要 |
The monoclonal antibody S19, expressed by Deposit HB12144, ATCC, effectively agglutinates a sperm surface glycoprotein, SAGA-1 protein. The mAB finds utility as a binding agent in a spermicide, showing a high degree of effectiveness in binding potential sperm. The protein bound, identified as SAGA-1, is the immunogen in a contraceptive vaccine, as well as the standard for determining antibody titer upon vaccination. The monoclonal antibody can also be used as a diagnostic to determine the presence, and amount, of sperm in a variety of samples.
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申请公布号 |
US5830472(A) |
申请公布日期 |
1998.11.03 |
申请号 |
US19960671622 |
申请日期 |
1996.06.28 |
申请人 |
THE UNIVERSITY OF VIRGINIA PATENT FOUNDATION |
发明人 |
HERR, JOHN C.;DIEKMAN, ALAN B.;NORTON, ELIZABETH;WESTBROOK-CASE, ANN |
分类号 |
G01N33/53;A61K39/00;A61K39/395;A61P15/18;A61P43/00;C07K14/705;C07K16/28;C12N15/02;C12P21/08;G01N33/577;(IPC1-7):A61K39/395;C07K16/00 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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