Antiproliferative vitamin D3 hybrids

摘要

Vitamin D3 analogues of formula <IMAGE> wherein R represents a 1-hydroxyalkyl group or 1-fluoroalkyl group in a trans- configuration with a 3-hydroxyl group on the A ring and R2 represents the substituents completing a vitamin D3 analogue. These novel compounds are potent anti-proliferative substances with activities comparable to that of calcitriol but with vitamin D3 receptor binding ratings of less than 10-3 compared to that of calcitriol.