发明名称 |
Identification of TRP-2 as a human tumor antigen recognized by cytotoxic T lymphocytes |
摘要 |
The infusion of TIL586 along with interleukin-2 (IL-2) into the autologous patient with metastatic melanoma resulted in the objective regression of tumor. A gene encoding a tumor antigen recognized by TIL586 was previously isolated and shown to encode gp75 or TRP-1. The present invention relates to the identification of a second tumor antigen recognized by a HLA-A31 restricted CTL clone derived from the TIL586 cell line. This antigen derived from the TRP-2 protein tumor antigen and peptides thereof are capable of sensitizing target cells for lysis by a CTL clone at 1 nM peptide concentration. Modified peptides were also recognized by the CTL clone.
|
申请公布号 |
US5831016(A) |
申请公布日期 |
1998.11.03 |
申请号 |
US19960725736 |
申请日期 |
1996.10.04 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
WANG, RONG-FU;ROSENBERG, STEVEN A. |
分类号 |
A61K38/00;A61K39/00;A61K48/00;C07K14/47;C12N9/02;C12N9/90;(IPC1-7):C07K7/06 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|