发明名称 |
Fibrin(ogen) degradation by fibrinolytic matrix metalloproteinase |
摘要 |
The invention provides a method of causing the degradation of fibrin(ogen) (i.e., fibrin, fibrinogen, and related substances) by means of a fibrinolytic metalloproteinase, such as MMP-3. The method of the invention may be performed in vitro to provide diagnostic information characterizing fibrin(ogen) and the fibrinolytic physiology. The method may also be performed in vivo as a method of thrombolytic therapy in which a fibrinolytic metalloproteinase is administered to a subject to degrade thrombus in situ. The invention further provides compositions containing a fibrinolytic metalloproteinase for the performance of fibrinolytic or thrombolytic procedures. Also provided are kits which include a fibrinolytic metalloproteinase for performing fibrinolytic or thrombolytic procedures.
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申请公布号 |
US5830468(A) |
申请公布日期 |
1998.11.03 |
申请号 |
US19950446887 |
申请日期 |
1995.05.17 |
申请人 |
THE NEW YORK BLOOD CENTER, INC. |
发明人 |
BINI, ALESSANDRA |
分类号 |
A61L33/00;A61K38/43;A61K38/46;A61K38/48;A61K38/55;A61K48/00;A61P7/02;A61P9/10;C07K1/12;(IPC1-7):A61K38/48;A61M5/00;B65D51/24;C12N9/50 |
主分类号 |
A61L33/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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