发明名称 |
Methods to prepare beta beta '-dihydroxy meso-substituted chlorins, isobacteriochlorins and bacteriochlorins |
摘要 |
A beta , beta '-dihydroxy meso-substituted chlorin, bacteriochlorin or isobacteriochlorin compound having the formula (I) or (II): <IMAGE> (I) or <IMAGE> (II) wherein M is a metal. A novel method for synthesizing the compound of formula (I) or (II) comprises the steps of: a. osmylating a beta . beta '-unsubstituted, meso-substituted porphyrin to form an osmate ester at the beta , beta '-position, and b. reducing the osmate ester to form the corresponding beta , beta '-dihydroxy meso-substituted chlorin, bacteriochlorin or isobacteriochlorin of formula (I) or (II).
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申请公布号 |
US5831088(A) |
申请公布日期 |
1998.11.03 |
申请号 |
US19970853115 |
申请日期 |
1997.05.08 |
申请人 |
THE UNIVERSITY OF BRITISH COLUMBIA |
发明人 |
DOLPHIN, DAVID;BRUECKNER, CHRISTIAN |
分类号 |
A61K31/40;A61K31/409;A61K49/06;A61K51/04;A61P35/00;C07D487/22;C07F1/08;C07F3/06;C07F5/00;C07F5/06;C07F7/10;C07F7/22;C07F7/30;C07F13/00;C07F15/04;(IPC1-7):C07D487/22 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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