发明名称 |
T-cell receptors and their use in therapeutic and diagnostic methods |
摘要 |
The present invention provides nucleic acid sequences for T-cell receptors which recognize tumor associated antigens. In particular, T-cell receptors which recognize melanoma antigens. This invention also provides T-cells expressing the antigen specific T-cell receptors. In addition, this invention provides stem cells expressing the antigen specific T-cell receptors or chimeric receptors. This invention further relates to therapeutic and diagnostic compositions and methods employing the T-cell receptors and chimeric receptors provided herein.
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申请公布号 |
US5830755(A) |
申请公布日期 |
1998.11.03 |
申请号 |
US19950411098 |
申请日期 |
1995.03.27 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
NISHIMURA, MICHAEL;ROSENBERG, STEVEN A. |
分类号 |
C12N15/09;A61K35/14;A61K35/28;A61K35/76;A61K38/00;A61K48/00;A61P35/00;C07K7/06;C07K14/725;C07K14/735;C07K16/28;C12N5/10;C12N15/12;(IPC1-7):C12N5/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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