发明名称 |
ISOLATION AND/OR PRESERVATION OF DENDRITIC CELLS FOR PROSTATE CANCER IMMUNOTHERAPY. |
摘要 |
Methods and compositions for use of human dendritic cells to activate T cells for immunotherapeutic responses against primary and metastatic prostate cancer are disclosed. In one embodiment, human dendritic cells, after exposure to a prostate cancer antigen or specific antigenic peptide, are administered to a prostate cancer patient to activate the relevant T cell responses in vivo. In an alternate embodiment, human dendritic cells are exposed to a prostate cancer antigen or specific antigenic peptide in vitro and incubated or cultured with primed or unprimed T cells to activate the relevant T cell responses in vitro. The activated T cells are then administered to a prostate cancer patient. Methods and compositions for human dendritic cells with extended life span and cryopreserved dendritic cells are disclosed.
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申请公布号 |
MX9800821(A) |
申请公布日期 |
1998.10.31 |
申请号 |
MX19980000821 |
申请日期 |
1998.01.29 |
申请人 |
PACIFIC NORTHWEST CANCER FOUNDATION |
发明人 |
GERALD P. MURPHY;ALTON L. BOYNTON;BENJAMIN A. TJOA |
分类号 |
A61K35/12;A61K35/14;A61K35/26;A61K39/00;A61P13/08;A61P35/00;A61P37/04;C07K7/06;C07K14/705;(IPC1-7):A61K39/00;A61K35/55;A61K38/04;C07K07/00 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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