| 摘要 |
Synthetic peptides of the monomer type with 13 to 33 amino acids, in linear form or in a form cyclized by means of inter-cysteine disulphide bridges, have the general formula (I): <?in-line-formulae description="In-line Formulae" end="lead"?>Delta-Z-TrpGlyCys-Theta-CysTyrThrSer-Omega (I)<?in-line-formulae description="In-line Formulae" end="tail"?> wherein Delta is a biotinyl radical, a biocytinyl radical, a hydrogen atom, an acetyl (CH<SUB>3</SUB>CO-) radical, an aliphatic chain which may contain one or two thiol, an aldehyde functional group, or an amine functional group, Z represents peptide sequence -Xi<SUB>1</SUB>-Ser-Xi<SUB>2</SUB>-, -Xi<SUB>1</SUB>-Gln-Xi<SUB>2</SUB>-, or -Xi<SUB>1</SUB>-Asn-Xi<SUB>2</SUB>-, wherein -Xi<SUB>1 </SUB>represents a peptide sequence of 0 to 9 amino acids and -Xi<SUB>2 </SUB>represents a peptide sequence of 0 to 5 amino acids, Theta is -Arg Gly Arg Leu Ile-(SEQ ID NO: 15), -Arg Gly Arg Leu Val-(SEQ ID NO: 16), -Arg Gly Lys Leu Ile- (SEQ ID NO: 17), -Arg Gly Lys Leu Val-(SEQ ID NO: 18), -Lys Gly Arg Leu Ile-(SEQ ID NO: 19), or -Lys Gly Arg Leu Val-(SEQ ID NO: 20), Omega, attached to the -CO- group of serine, is a hydroxyl (-OH) radical, an amino (-NH<SUB>2</SUB>) radical, an alkoxy radical having 1 to 6 carbon atoms, a peptide sequence of formula Val-Sigma-Psi wherein Sigma represents a sequence of formula -(AA<SUB>1</SUB>)-Trp Asn-(AA<SUB>2</SUB>)-(AA<SUB>3</SUB>) wherein (AA<SUB>1</SUB>) represents an amino acid different from lysine, (AA<SUB>2</SUB>) represents an amino acid, and (AA<SUB>3</SUB>) is serine or a threonine residue, and Psi, attached to the -CO- residue of the free AA<SUB>3 </SUB>amino acid, is OH, NH<SUB>2</SUB>, or an alkoxy radical having from 1 to 6 carbon atoms, and a peptide sequence of formula -Val-Psi wherein Psi, attached to the -CO- residue of valine, is OH, NH<SUB>2</SUB>, or an alkoxy radical having from 1 to 6 carbon atoms. |
