发明名称 |
Compounds and methods for inhibiting the interaction between alpha-catenin and beta-catenin |
摘要 |
Modulating agents for inhibiting an interaction between alpha-catenin and beta-catenin are provided. The modulating agents comprise one or more of: (a) a beta-catenin HAV motif; (b) a peptide analogue or mimetic of a beta-catenin HAV motif; or (c) an antibody or antigen-binding fragment thereof that specifically binds to a beta-catenin HAV motif. Methods for using such modulating agents for inhibiting cadherin-mediated cell adhesion in a variety of contexts are also provided. |
申请公布号 |
AU6914798(A) |
申请公布日期 |
1998.10.30 |
申请号 |
AU19980069147 |
申请日期 |
1998.04.14 |
申请人 |
OREST W. BLASCHUK |
发明人 |
OREST W. BLASCHUK;BARBARA J. GOUR |
分类号 |
A61K38/00;C07K14/705 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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