发明名称 |
REGULATORY SYSTEM FOR INDUCIBLE EXPRESSION OF GENES WITH LAMBDOID PROMOTERS |
摘要 |
The invention relates to a regulation system for inducible expression of genes, comprising a lambdoid promoter, a gene coding for a repressor for the lambdoid promotor and a gene coding for an antirepressor of the repressor, which antirepressor is under the influence of an inducible promotor. The invention further relates to a regulatory replicon, comprising said gene coding for an antirepressor, an expression system, comprising said regulatory replicon, and an expression vector based on a lambdoid promotor, and also to a method for producing a gene product in a heterologous host, by providing a culture of a host comprising a heterologous sequence which codes for the gene product, wherein the expression of the heterologous sequence is under the control of a regulation system, a gene coding for a repressor for the lambdoid promotor and a gene coding for an antirepressor, and by inducing the promotor of the antirepressor gene. |
申请公布号 |
WO9848025(A2) |
申请公布日期 |
1998.10.29 |
申请号 |
WO1998EP02465 |
申请日期 |
1998.04.23 |
申请人 |
VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE;MERTENS, NICO, MAURICE, AUGUST, CORNEEL;REMAUT, ERIK, RENE;FIERS, WALTER, CHARLES |
发明人 |
MERTENS, NICO, MAURICE, AUGUST, CORNEEL;REMAUT, ERIK, RENE;FIERS, WALTER, CHARLES |
分类号 |
C12N15/09;A61K38/00;A61K45/00;A61K48/00;A61P43/00;C07K14/01;C07K14/52;C12N1/21;C12N9/02;C12N15/63;C12N15/73;C12P21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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