A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.
申请公布号
WO9847524(A1)
申请公布日期
1998.10.29
申请号
WO1998US07990
申请日期
1998.04.22
申请人
CURATOR OF THE UNIVERSITY OF MISSOURI;HOFFMAN, TIMOTHY;VOLKERT, WYNN, A.;NING, LI;SIECKMAN, GARY;HIGGENBOTHAM, CHRYS, A.
发明人
HOFFMAN, TIMOTHY;VOLKERT, WYNN, A.;NING, LI;SIECKMAN, GARY;HIGGENBOTHAM, CHRYS, A.