发明名称 |
A PURIFIED 20 KDA PRESENILIN 2 C-TERMINAL FRAGMENT AND METHODS OF SCREENING FOR COMPOUNDS THAT INHIBIT PROTEOLYSIS OF PRESENILIN 2 |
摘要 |
The present invention relates, in general, to presenilin 2 proteolytic fragments. In particular, the present invention relates to a purified 20 kDa presenilin 2 C-terminal fragment (PS2-CTF); purified nucleic acid molecules coding for the 20 kDa PS2-CTF protein; cells containing the nucleic acid molecules; non-human organisms containing the nucleic acid molecule; antibodies having specific binding affinity to the 20 kDa PS2-CTF; hybridomas containing the antibodies; methods of detecting 20 kDa PS2-CTF in a sample; diagnostic kits; methods for screening compounds that inhibit proteolytic processing of presenilin 2 in a cell, isolated compounds that inhibit proteolytic processing of presenilin 2 in a cell, and a method of inhibiting apoptotic cell death by preventing proteolytic cleavage of presenilin 2 at a cleavage site which generates a 20 kDa C-terminal fragment.
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申请公布号 |
CA2288227(A1) |
申请公布日期 |
1998.10.29 |
申请号 |
CA19982288227 |
申请日期 |
1998.04.24 |
申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
TANZI, RUDOLPH E.;KIM, TAE-WAN |
分类号 |
A01K67/027;A61K38/00;A61P25/28;C07K14/47;C07K16/18;C12N5/10;C12N15/02;C12N15/09;G01N33/15;G01N33/50;G01N33/53;(IPC1-7):C12N15/12;C12N5/12;A61K38/17;G01N33/577;G01N33/68 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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