BRCA2 TRANSCRIPTIONAL ACTIVATOR DOMAIN AND USES THEREOF

摘要

Exon 3 of BRCA2 encodes a transcriptional activator domain ("TAD"), including a primary activating region ("PAR") and an auxiliary activating region ("AAR"), flanked by two inhibitory regions ("IR1" and "IR2") which are bound by molecules which inhibit activation of transcription by the TAD. Appropriate fragments of BRCA2 polypeptide are useful in activating transcription and in assays for substances able to modulate transcriptional activation by BRCA2.