摘要 |
<p>The invention relates to a method for controlling the solubility of a β-lactam nucleus having general formula (I) wherein R0 is hydrogen or C1-3 alkoxy; Y is CH2, oxygen, sulfur, or an oxidized form of sulfur; and Z is (a, b, c, or d) wherein R1 is hydrogen, hydroxy, halogen, C1-3 alkoxy, optionally substituted, optionally containing one or more heteroatoms, saturated or unsaturated, branched or straight C1-5 alkyl, preferably methyl, optionally substituted, optionally containing one or more heteroatoms C5-8 cycloalkyl, optionally substituted aryl or heteroaryl, or optionally substituted benzyl, or of a salt of said β-lactam nucleus, wherein the amphoteric properties of said β-lactam nucleus or the salt thereof are modified.</p> |