4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS

摘要

The present invention provides a compound of formula (I), wherein ring A is an optionally substituted aromatic hydrocarbon ring or aromatic heterocyclic ring; ring B is an optionally substituted aromatic hydrocarbon ring or aromatic heterocyclic ring; Z is an optionally substituted cyclic group or linear hydrocarbon group; R1 is a hydrogen atom, an optionally substituted hydrocarbon group or heterocyclic ring; R2 is an optionally substituted amino group; D is a bond or an optionally substituted divalent hydrocarbon ring; E is a bond, -CON(Ra)-, -N(Ra)CO-, -N(R?b)CON(Rc¿)-, -N(Rd)COO-, -N(Re)SO2-, -COO-, -N(Rf)-, -O-, -S-, -SO-, -SO¿2?-, and formula (a) or (b) (in which R?a, Rb, Rc, Rd, Re and Rf¿ are respectively a hydrogen atom or an optionally substituted hydrocarbon group); G is a bond or an optionally divalent substituted hydrocarbon group; L is a divalent group; ring B may form an optionally substituted non-aromatic condensed nitrogen-containing heterocyclic ring by combining with R2; X is two hydrogen atoms, an oxygen atom or a sulfur atom; ......... is a single bond or a double bond, and Y is a nitrogen atom when ......... is a double bond, or an oxygen atom, -N(R4)-, (in which R4 is a hydrogen atom, an optionally substituted hydrocarbon group or an acyl group) or S(O)¿n? (in which n is 0, 1 or 2) when ......... is a single bond, or a salt thereof, which have somatostatin receptor agonistic action.