发明名称 |
Cyclosporin a formulations as nanoparticles |
摘要 |
Cyclosporin A formulations are provided as amorphous nanoparticle dispersions for physiologic absorption. The compositions have high bioavailability and patient acceptability. By providing for concentrates comprising lower alkanols and a polyoxyalkylene surfactant as a stable dispersion of cyclosporin A, upon introducing the stable dispersion into an aqueous medium, the subject formulation is produced comprising amorphous bioavailable cyclosporin nanoparticles.
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申请公布号 |
US5827822(A) |
申请公布日期 |
1998.10.27 |
申请号 |
US19960622516 |
申请日期 |
1996.03.25 |
申请人 |
SANGSTAT MEDICAL CORPORATION |
发明人 |
FLOC'H, ROBERT;MERLE, CHRISTIAN |
分类号 |
A61K9/10;A61K9/48;A61K38/13;A61K47/10;A61K47/14;A61K47/26;(IPC1-7):A61K9/10 |
主分类号 |
A61K9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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