| 摘要 |
FIELD: organic chemistry, chemistry of peptides. SUBSTANCE: invention relates to derivatives of polypeptides of the general formula (I): $$$ where A: $$$ is Leu-Phe-Glu-Cys-Cys-Leu-Gly- -Glu-; Cys-Ala-Glu-Phe-; Ser-Cys-Gly-His-; Leu-Ile-Glu-Cys-; $$$ is Ala, Val, Gln, Asn; B: $$$ is Leu-Ser-Cys-Asp-; Ser-Lys-Cys-Lys-; Gly-Thr-Pro-Cys-; Val-Pro-Cys-Asp-; Phe-Ser- -Cys-Asp-; $$$ is Ile, Lys, Glu; C: $$$ is Lys-Lys-Asn-Gly-; Asp-Ser-Gly-Cys-; Lys-Asn-Trp-Asp-; Thr-Lys-Asn-Gly-; Asp-Arg-Pro-Asn; $$$ is Lys, Cys; D: $$$ is Pro-Cys-Lys-Pro-; Gly-Thr-Leu-Glu-; Cys-Lys-Gly-Lys-; Cys-Ser-Lys-Thr-; $$$ is Cys, Val, Gly, Lys; E: $$$ is Gly-Glu-Lys-Lys-; Ser-Pro-Thr- -Trp-; Cys-Leu-Glu-Pro-; $$$ is Cys, Lys, Trp, Thr; F: $$$ is Ser-Gly-Gly-Trp-; Trp-Cys-Val-Tyr-; Lys-Leu-Cys-Ala-; Gly-Tyr- -Gly-Arg; $$$ is Arg, Cys, Pro, Tyr; G: $$$ is Cys-Lys-Ile- -Asn-; Ser-Pro-Phe-; Glu-Ser-Pro-Phe-; Tyr-Ala-Ser-Tyr-; Cys-Leu-Lys-Val-; $$$ is Phe, Tyr, simple bond; Z is OH, Cys- -Leu-Lys-Val-OH, Cys-Leu-Ile-OH; Ser-Tyr-Lys-Thr-Leu-OH being six cysteine residues in compound (I) are bound by disulfide bonds. Method of inhibition of calcium channel involves administration of polypeptide in cell at effective amount. Invention can be used in medicine for treatment of mammals with sicknesses mediated by calcium channels. EFFECT: simplified method, enhanced effectiveness of method. 3 cl, 9 ex, 9 tbl
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