New T4 lysozyme polypeptide compounds

摘要

The present invention relates to lysozym-analogous proteins and peptides having an anti-microbial activity, to the production of the same and the use of said proteins and peptides. These proteins and peptides are recombinantly modified or modified by mutations only as far as their main properties are preserved, especially the anti-microbial properties of the T4 lysozyme and except for the muramidase activity. This invention also relates to recombinant proteins which contain at least the amino acids 126-141 or 143-155 of the T4 lysozyme. This invention further relates to the production of said proteins and peptides from their coding genes, wherein said production comprises carrying out their bio-synthesis in prokaryotic and eukaryotic organisms as well as using chemically-synthesised proteins or peptides. This invention finally relates to the use of these proteins and peptides as medical active agents, as food additives and animal-food additives or as other in vivo and in vitro anti-microbial protection materials or as exogenic proteins in transgenic organisms.