发明名称 |
METHODS FOR SYNTHESIZING 2-SUBSTITUTED IMIDAZOLES |
摘要 |
The present invention is a method of preparing 2-substituted imidazoles from readily available imidazoles having a leaving group in the 2-position, by alkylating the imidazole under mild conditions to afford a 3-N-alkylated imidazolium salt; and coupling the imidazolium salt with a nucleophile also under mild conditions to afford a 2-substituted 3-N-alkylated imidazolium salt. The reaction product can optionally be isolated and purified. The 2-substituted 3-N-alkylated imidazolium salt is hydrolyzed to afford a 2-substituted imidazole. Alternatively, the imidazole is coupled with a nucleophile in the presence of fluoride ion to provide a 2-substituted imidazole.
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申请公布号 |
WO9846571(A1) |
申请公布日期 |
1998.10.22 |
申请号 |
WO1998US07614 |
申请日期 |
1998.04.17 |
申请人 |
SEPRACOR INC. |
发明人 |
HONG, YAPING;BAKALE, ROGER, P.;SENANAYAKE, CHRISANTHA, H. |
分类号 |
C07D233/66;C07D401/04;C07D401/12;(IPC1-7):C07D233/44;C07D233/48;C07D233/46;C07D401/00;C07D405/00;C07D409/00;C07D411/00;C07D413/00;C07D417/00;C07D419/00;C07D421/00 |
主分类号 |
C07D233/66 |
代理机构 |
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主权项 |
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地址 |
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